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Dr. Daniele Merico

Senior Director of Target Identification at Deep Genomics

Toronto, CA

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About

I have over 15 years experience and over 80 peer-reviewed publications in human genetics, genomics and systems biology. I have worked on the genetics of rare monogenic disorders and more genetically complex neuropsychiatric disorders, with a special focus on rare copy number variants, splicing alterations and pathway/network analysis. In my current position at Deep Genomics, I am responsible for the identification of rare disorder targets for oligonucleotide therapeutics development, and managing the initial steps of therapeutic development. I have the privilege of working with world-class experts in machine learning, genomics and oligonucleotide therapeutics.

Ask me about
rare disorders
human genetics
nucleic acid therapeutics
artificial intelligence
systems biology
genomics
target identification
therapeutic portfolio management
drug discovery
whole exome sequencing
whole genome sequencing
RNA-seq
pathway analysis
gene networks
Clinvar
OMIM
UK BioBank
gnomAD
allStripes
GalNAc
Autism
Work experience
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Jan 2021 - Present

Deep Genomics

Senior Director of Target Identification

* Member of the leadership team, contribution to strategic decisions for business, science and technology platform * Responsible for the identification of genetic disorder targets for oligonucleotide therapeutics * Team leadership: 2 senior research scientists, 1 research scientist, 1 bioinformatician and 1 software developer

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Jun 2020 - Present

The Hospital for Sick Children

Associate Investigator (honorary position)

The Centre for Applied Genomics (TCAG) * Identification of causal variants for Mendelian disorders (focus on immune deficiencies) * Analysis of rare genetic variants in complex neuropsychiatric disorders

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Feb 2020 - Present

Deep Genomics

Interim Co-Director of Preclinical Research

* Responsible for early pre-clinical therapeutic development (in-vitro screening for oligonucleotide efficacy and safety) * Team leadership: 1 senior research scientists, 3 research scientists, 5 laboratory technicians

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Apr 2017 - Jan 2021

Deep Genomics

Director of Target Identification

* Member of the leadership team, contribution to strategic decisions for business, science and technology platform * Responsible for the identification of rare genetic disorder targets for oligonucleotide therapeutics * Team leadership: 2 senior research scientists, 1 bioinformatician and 1 software developer

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Feb 2016 - Jun 2020

The Hospital for Sick Children

Visiting Scientist

The Centre for Applied Genomics (TCAG) * Identification of causal variants for Mendelian disorders (focus on immune deficiencies, intellectual disability and developmental syndromes) * Analysis of rare genetic variants in complex neuropsychiatric disorders, with a focus on network and pathway analysis * Evaluation and optimization of copy number variant calling methods for Illumina whole genome sequencing (i.e. short reads)

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Jan 2019 - Apr 2019

Deep Genomics

Interim Director of Preclinical Therapeutic Development

* Responsible for early pre-clinical therapeutic development (in-vitro screening for oligonucleotide efficacy and safety) * Team leadership: 3 research scientists, 4 laboratory technicians

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Oct 2015 - Apr 2017

Deep Genomics Inc.

Director of Molecular Diagnostics

* Member of the leadership team * Responsible for: performance evaluation of genetic variant molecular effect predictors; collaborative projects to understand the genetics of Mendelian and complex disorders * Team leadership: 1 research scientist and 1 bioinformatician

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May 2011 - Feb 2016

The Hospital for Sick Children

Informatics Core Facility Manager

The Centre for Applied Genomics (TCAG): * Development of variant annotation and prioritization pipelines for Mendelian disorder variant discovery * Identification of causal variants in Mendelian disorders * Variant calling and QC pipeline assessment (Complete Genomics, LifeTech Ion Proton, BWA/GATK, Illumina HAS) * MSSNG project (10,000 whole genome sequencing resource for autism): contribution to the user interface design and analysis pipeline design * Network and pathway analysis of rare genetic variants in complex neuropsychiatric disorders (AGP international consortium, PGC international consortium) * Responsible for the next generation sequencing bioinformatics analysis service: whole exome sequencing, whole genome sequencing, RNA-seq, ChIP-seq, de novo transcriptome / genome assembly * Team leadership: 10 bioinformaticians

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Jan 2009 - May 2011

University of Toronto

Post-doctoral Research Fellow

Prof. Gary Bader's Lab (Donnelly Centre) * Pathway and network analysis method development (Cytoscape plugins: Enrichment Map, WordCloud) * Pathway and network analysis of microarray gene expression data for murine cancer models

Nov 2005 - Dec 2008

Università degli Studi di Milano

Graduate Student (Ph.D. Molecular and Cellular Biology)

Prof. Roberto Mantovani's lab * ChIP-chip and gene expression data analysis to characterize the p63 and NF-Y transcription factor targets

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Oct 2007 - Oct 2008

University of Toronto

Visiting Graduate Student

Prof. Gary Bader's Lab (Donnelly Centre) * Pathway and network analysis of microarray gene expression data and proteomics data for murine cardiomyopathy models

2004 - 2005

Università degli Studi di Milano-Bicocca

Graduate Student (M.Sc. Bioinformatics)

Prof. Paola Castagnoli's lab * Microarray gene expression data analysis for immunology

Education

2005 - 2009

Università degli Studi di Milano

Ph.D. in Molecular and Cellular Biology, (Genomics, Bioinformatics, Molecular Biology)

2003 - 2005

Università degli Studi di Milano-Bicocca

Master of Science in Bioinformatics, (Bioinformatics, Computational Biology, Genomics)

2000 - 2003

Università degli Studi di Milano-Bicocca

Bachelor of Science in Molecular Biotechnology, (Molecular Biology, Biochemistry, Chemistry, Genetics, Biotechnology)

1995 - 2000

Liceo Statale Scientifico e Classico "Ettore Majorana"​

high school diploma, Scientific track

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