About
Focus areas:
- medical bioinformatics
- translational research
- cancer biology
- immunology
- dermatology
- inflammatory skin diseases
Current work and major fields of interest:
- drug-target interaction studies
- molecular biomarkers
- miRNA discovery and analysis
- ABC transporters
- atopic dermatitis
- psoriasis
- Kinetic and structure-activity (QSAR) analysis of ATPase and transport data
- Protein work:
-> Cross-linking studies and immunological assays:
-> Antibody design and production
-> Immunoprecipitation and Western blotting
-> Immunohistochemistry (light microscopy and electron microscopy)
- Confocal microscopy:
-> Transport and co-localization assays with fluorescent substrates
-> Fluorescence immunohistochemistry
- Bioinformatics:
-> Structural and functional analysis of ABC transport proteins, including
-> Sequence homology and phylogenetic analysis
-> Structure-activity relationship (SAR) analysis
-> Knowledge database for multidrug resistance reversal data.
-> Expression analysis (SAGE, microarrays. RNA-seq)
-> meta-analysis of expression data (interaction networks)
Specialties: biomarker discovery
miRNA research
cancer and inflammation
multidrug resistance
ABC transporters
bioinformatics
dermatology
Ask me about
Work experience
- December 2015 – present
University of Copenhagen
Professor in medical bioinformatics and inflammatory skin diseases - September 2011 – present
LEO Pharma
Principal ScientistI integrate bioinformatics at LEO Pharma. My tasks include (but are not limited to .-): - managing and integrating external as well as internal -omics studies (GEO2LEO) - transcriptomics (mRNA, miRNA) - proteomics (phosphoprotemoics) - biomarker discovery - translational research - supervision - April 2011 – August 2011
University of Copenhagen
Associate Research ProfessorKey research areas: Discovery of molecular biomarkers, such as microRNA, for cancer Deciphering drug resistance (ABC transporters, MDR, MXR) Bioinformatics: microarray (mRNA, miRNA, protein) data analysis - January 2010 – August 2011
Litman Consulting
OwnerBioinformatics data analysis after 5 pm .-) - January 2006 – June 2010
Exiqon
Head of Department, Biomarker DiscoveryHead of the Biomarker Discovery department at Exiqon. Investigating potential new miRNA biomarkers with relevance for cancer diagnostics, prognostics and prediction of treatment response. - January 2003 – December 2005
University of Copenhagen
Associate ProfessorMedical Bioinformatics - January 2002 – December 2002
University of Copenhagen
Weimann Associate ProfessorCancer research, multidrug resistance transporters, P-glycoprotein, MXR / ABCG2 - January 1999 – January 2002
Panum Institute
Associate Research Professorbioinformatics - January 1997 – January 1999
NIH
post doccancer research - January 1997 – January 1999
National Cancer Institute
post docmultidrug resistance
Education
- 2006 – 2014
Københavns Universitet
Open University (after hours) Bachelor Degree, Philosophy & Rhetoric - 2010 – 2010
Niels Brock
Systemic Coaching, Systemic Coaching - 1993 – 1996
University of Copenhagen
Ph.D., medicine - 1987 – 1992
The Technical University of Denmark
M.S.Ch.E, Biochemical Engineering - 1989 – 1991
University of Copenhagen
M.Sc., Human Biology - 1983 – 1986
Gladsaxe Gymnasium
high-school certificate, mat fys - 1977 – 1983
Gladsaxe Privatskole
folkeskolens afgangsprøve, Folkeskolens afgangsprøve