T

Thomas Litman

Data --> information --> knowledge --> decisions

Copenhagen, DK

About

Focus areas: - medical bioinformatics - translational research - cancer biology - immunology - dermatology - inflammatory skin diseases Current work and major fields of interest: - drug-target interaction studies - molecular biomarkers - miRNA discovery and analysis - ABC transporters - atopic dermatitis - psoriasis - Kinetic and structure-activity (QSAR) analysis of ATPase and transport data - Protein work: -> Cross-linking studies and immunological assays: -> Antibody design and production -> Immunoprecipitation and Western blotting -> Immunohistochemistry (light microscopy and electron microscopy) - Confocal microscopy: -> Transport and co-localization assays with fluorescent substrates -> Fluorescence immunohistochemistry - Bioinformatics: -> Structural and functional analysis of ABC transport proteins, including -> Sequence homology and phylogenetic analysis -> Structure-activity relationship (SAR) analysis -> Knowledge database for multidrug resistance reversal data. -> Expression analysis (SAGE, microarrays. RNA-seq) -> meta-analysis of expression data (interaction networks) Specialties: biomarker discovery miRNA research cancer and inflammation multidrug resistance ABC transporters bioinformatics dermatology

Ask me about

Work experience

  1. December 2015 – present

    University of Copenhagen

    Professor in medical bioinformatics and inflammatory skin diseases
  2. September 2011 – present

    LEO Pharma

    Principal Scientist
    I integrate bioinformatics at LEO Pharma. My tasks include (but are not limited to .-): - managing and integrating external as well as internal -omics studies (GEO2LEO) - transcriptomics (mRNA, miRNA) - proteomics (phosphoprotemoics) - biomarker discovery - translational research - supervision
  3. April 2011 – August 2011

    University of Copenhagen

    Associate Research Professor
    Key research areas: Discovery of molecular biomarkers, such as microRNA, for cancer Deciphering drug resistance (ABC transporters, MDR, MXR) Bioinformatics: microarray (mRNA, miRNA, protein) data analysis
  4. January 2010 – August 2011

    Litman Consulting

    Owner
    Bioinformatics data analysis after 5 pm .-)
  5. January 2006 – June 2010

    Exiqon

    Head of Department, Biomarker Discovery
    Head of the Biomarker Discovery department at Exiqon. Investigating potential new miRNA biomarkers with relevance for cancer diagnostics, prognostics and prediction of treatment response.
  6. January 2003 – December 2005

    University of Copenhagen

    Associate Professor
    Medical Bioinformatics
  7. January 2002 – December 2002

    University of Copenhagen

    Weimann Associate Professor
    Cancer research, multidrug resistance transporters, P-glycoprotein, MXR / ABCG2
  8. January 1999 – January 2002

    Panum Institute

    Associate Research Professor
    bioinformatics
  9. January 1997 – January 1999

    NIH

    post doc
    cancer research
  10. January 1997 – January 1999

    National Cancer Institute

    post doc
    multidrug resistance

Education

  1. 2006 – 2014

    Københavns Universitet

    Open University (after hours) Bachelor Degree, Philosophy & Rhetoric
  2. 2010 – 2010

    Niels Brock

    Systemic Coaching, Systemic Coaching
  3. 1993 – 1996

    University of Copenhagen

    Ph.D., medicine
  4. 1987 – 1992

    The Technical University of Denmark

    M.S.Ch.E, Biochemical Engineering
  5. 1989 – 1991

    University of Copenhagen

    M.Sc., Human Biology
  6. 1983 – 1986

    Gladsaxe Gymnasium

    high-school certificate, mat fys
  7. 1977 – 1983

    Gladsaxe Privatskole

    folkeskolens afgangsprøve, Folkeskolens afgangsprøve
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