J
Julie Rice

Director of Operations

3

Office Hours

How does this work?
About

- over 25 years in the Bay Area biotechnology industry - diverse laboratory background: molecular biology, cell biology, enzymology, assay development, high-throughput screening, robotics, EH&S, procurement, relational databases, data analysis, supervisory roles (summer interns and research associates) - worked in companies focused on small-molecule drug discovery, RNA therapeutics and genomics - excellent multitasking, organizational, interpersonal and communication skills - Certificate in Project Management from UC Berkeley Extension

Ask me about
TetraScience
Prendio
Point Purchasing
Zageno
Bill.com
Quartzy
QuickBooks Online
Verkada
Laboratory construction
Tenant improvements
Company moves
Laboratory moves
Klatu
Zluri
CDD Vault
Benchling
Gusto Payroll
Biotechnology Startups
Drug Discovery
Work experience
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Sep 2021 - Present

Blade Therapeutics

Director of Facilities and Operations

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Jun 2020 - Sep 2021

Boost Biomes

Director of Operations

Laboratory operations: EHS, procurement, Import-Export, Compliance, Equipment maintenance, office/laboratory tenant improvements, capital equipment price negotiations and purchases, laboratory infrastructure setup Business operations: Human Resources, Accounting, Facilities, Regulatory, Project Management, IT coordinator, contract review

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Aug 2018 - Jun 2020

Maze Therapeutics

Senior Manager, Operations

• Overseeing startup operations for two Third Rock Ventures “NewCo’s” • Planning and improvement of facilities at a temporary site, and overseeing two multi-million dollar tenant improvement projects at The Cove in South San Francisco; working directly with construction project managers, general contractors and all trades • Coordinated move of both companies from Redwood City to South San Francisco • Involved in most capital equipment purchases including instrument evaluations, price negotiations, service contracts, installation, routine maintenance, calibration, certification and repair • Facilities coordinator of all services for plumbing, mechanical, electrical, moving, storage and janitorial • Implemented a remote monitoring system for cold storage, incubators, switchover manifolds and process gasses • Coordinating stockroom management with primary lab supply vendors • Working closely with our EHS consultant to establish a fully compliant laboratory and workplace environment; head of Safety Committee/Biosafety Officer • Supervising one full-time materials handler and one part-time facilities technician

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Aug 2018 - Dec 2019

Third Rock Ventures

Consultant

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Aug 2018 - Dec 2019

Ambys Medicines

Operations Consultant

Apr 2017 - Aug 2018

Pharmacyclics, an AbbVie Company

Laboratory Manager

• Member of the senior staff reporting to the Head of Research, directly supporting 30+ researchers in the Research and Translational Medicine groups; providing backup support to the Medicinal Chemistry and DMPK groups; supervised one operations assistant • The main point of contact for laboratory operations, interfacing with the following entities: Internal - Facilities, IT, EH&S, shipping and receiving, procurement, finance, legal, AbbVie counterparts Please see my CV for details regarding my involvement in the following: compound management, project management, finance, procurement, information technology IT, facilities, EH&S, laboratory management, GCP compliance, import/export

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Jul 2016 - Mar 2017

Surrozen

Senior Manager, Operations

• Reported directly to the Chief Scientific Officer and overseeing all operations for a startup company focused on regenerative medicine via the Wnt pathway. Working closely with both scientific staff and support staff, including finance, procurement, facilities, human resources, EH&S and IT. • Project Management: formalized meetings and communications; assisted scientists to “projectize” their research; worked with a consulting architect on a ground-up tenant improvement at The Cove in South San Francisco; managed a project to add office space to our temporary facility • Lab Management: identified EH&S needs then collaborated with a consultant for regulatory compliance; implemented an electronic lab notebook (ELN) and a relational database; vendor management to source supplies and services; responsible for equipment acquisition and maintenance; delegated duties to laboratory staff; organized a stockroom program and tracked inventory; identified bottlenecks and issues in order to optimize laboratory workflows • Operations Management: continuously improved processes; created a method to do a regular cost analysis of research activities; devised cost-saving strategies and negotiated prices to stay on or under budget; coordinated efforts between staff and the IT consultant to rollout a mixed operating system environment

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Nov 2015 - Jul 2016

Genentech

Bioanalytical Project Manager (Consultant)

• Working with Atezolizumab (anti-PDL1) Phase 1, 2, 3 clinical study teams, contracting group, data group, DMPK, BAS, central labs and contract labs to outsource and manage biosample (PK/ATA) analysis • Acting as ad hoc team member on multiple clinical study management teams (11) • Managing clinical vendor contracts which includes development of assay vendor SOWs, review of invoices, ensuring receipt of deliverables, resolving or escalating issues where needed, and closing contracts • Assist with identifying  and on-boarding assay vendors, drafting RFP, budget planning, and specifying data formats  • Preparing vendor oversight plans for each study as needed; reviewing study protocols and ICFs Ensure alignment between cross functional teams including documentation of decisions and action items • Collaborating with Clinical Pharmacologists and Study Data Managers to develop timelines for PK and ATA data, and managing relationships with contract labs ensuring timely completion of SOW deliverables • Overseeing shipping and receipt of biosamples from central labs to assay laboratories  • Providing biosample metrics and status updates to study management teams as requested  • Supporting clinical study teams / pharmacology teams by planning and attending appropriate meetings as needed  • Serving as the on-going operational point of contact between internal gRED functions and assay vendors for communication regarding sample logistics and availability, batching and testing timelines, reanalysis, and data reportable tracking 

Nov 2011 - Nov 2015

Cleave Biosciences

Scientist / Laboratory Operations Manager

• Laboratory Management: new laboratory set-up, purchasing, EH&S, administration of cloud-based electronic laboratory notebooks and a cloud-based relational database, managing vendors and consultants relating to all laboratory supplies and services, contract negotiation, cost analysis, sourcing new and used equipment, coordinated implementation of a remote equipment alarm notification • Project Management: implementation of laboratory management software; vendor streamlining and compliance • Managed RNAseq and CRISPR projects, collaborating with CROs and internal scientists; spearheading efforts to bring RNAseq and complementary qPCR technologies in-house • Managed clonal isolation of drug resistant human colon carcinoma cells, testing compounds for cell viability and preparing samples for sequencing and gene expression • Researching, designing and executing exploratory experiments for non-oncology indications • Coordinating scale-up of several cell lines for Xenograft studies (50-150 animals per study) • Responsible for maintaining a cell bank of over 200 cell lines • Assay development for GFP reporter cell lines using a Guava Flow Cytometer • Executed two HTS campaigns of small molecule libraries for new targets • Developed and screened high-content immunofluorescent microscopy assays using a high-throughput microscope • IC50 determination of small molecule inhibitors in cell viability, kinetics, apoptosis and washout assays • Evaluating gene expression profiles using TaqMan qPCR, and pathway regulation via reporter gene assays

May 2006 - Oct 2011

Sirna Therapeutics (a wholly owned subsidiary of Merck & Co., Inc.)

Research Biologist / Laboratory Manager, Lead Development Department

• Developed and optimized in vitro assays including transfection of siRNAs into immortalized cell lines, RNA isolation, analysis using one-step and two-step real-time RT - qPCR (TaqMan) • Isolated RNA from tissue and analyzed samples via RT - qPCR • Assessment of RNA quality using the Agilent Bioanalyzer and ThermoScientific Nanodrop • Determined protein expression using Western blot analysis and ELISAs • Processes tracked through LIMS and incorporated laboratory automation - Beckman Biomek FX and NX • Liaison between scientific staff and EHS, procurement, accounting, facilities, IT staff • Responsible for bulk reagent purchasing and the main contact for external vendors • Optimized workflows for efficiency, safety, ergonomics • Chosen as a Source-to-Settle Divisional Champion to assist in Merck’s transition to SAP • Coordinate equipment maintenance with Perkin-Elmer LAMP, facilities staff and manufacturers • Assist the Methods Development group track reagent consumption and purchase of capital equipment; negotiated over $1 million in savings for FY 2010 • Completed Merck Six Sigma Yellow Belt Training, and U.S. DOT 49 CFR / IATA Training • As a safety committee member and lab manager, conduct monthly safety inspections and resolve safety issues

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Mar 2002 - May 2006

Plexxikon, Inc.

Associate Scientist, Assay Development/Screening Department

• Responsible for carrying out initial assay development, high-throughput screening and cell-based assay work on the BRAF V600E project which eventually resulted in Vemurafenib (PLX4032), http://en.wikipedia.org/wiki/Vemurafenib • Assisted in implementation of a relational database for compound library information and screening data (MDL AssayExplorer, ChemDraw, PlateManager, ReportManager) • Developed AlphaScreen™ assays for several Serine/Threonine and Tyrosine kinases and responsible for screening of our compound libraries once the assays were developed • Developed follow-up cell-based assays that include cell proliferation, apoptosis, 293T transient transfections, glucose uptake, Western blotting and ELISA • Cloned and purified several kinases • Laboratory automation - Beckman Biomek FX

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Nov 1999 - Mar 2002

Deltagen, Inc.

Senior Research Associate, Genotyping Department

• Managed and supervised a genotyping department for a large mouse facility • Responsibilities included PCR primer design for target genes, troubleshooting PCR, BLAST searches of appropriate databases for assembly of sequence into contigs, and supervised nine Research Associates

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Sep 1998 - Nov 1999

Axys Pharmaceuticals, Inc.

Research Associate II

• Utilized various molecular and cell biology techniques to clone a protease for stable expression in mammalian cells (CHO) • Assisted in high-throughput screening projects and an antisense oligonucleotide project

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Jun 1997 - Sep 1998

Tularik, Inc.

Research Assistant / Associate, Drug Discovery Department

• Coordinated and performed high-throughput, cell-based screening and several follow-up in vitro assays for the Obesity/Diabetes project, studying agonists and antagonists of the transcription factor PPARγ and upregulators of the Ob gene • Ob gene Project – screened ~500,000 compounds; started assay development for DNA binding/Gel Shift studies and expression studies: an ELISA to detect leptin levels, luciferase assays, RNA isolation for competitive RT-PCR and an RNase Protection Assay • PPARγ Project - responsible for testing lead compounds in standard binding and reversibility assays, and in in vitro assays; in vitro assays included testing cytotoxicity of compounds using Alamar Blue, differentiating cells and cell staining using Oil Red O, detecting luciferase reporter gene expression in transient transfected cells • Laboratory automation - Titertek Multidrop, Torcon, Hydra96, Packard Topcount

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Sep 1996 - Jun 1997

Cor Therapeutics, Inc.

Research Associate II, High-throughput Screening Department

• Aided in the development of a centralized compound screening program, optimized and validated screening assays determining Adenylyl Cyclase activity, operated automated systems to carry out high-throughput screening and to process a large compound library • Experience with SPA (Scintillation Proximity Assay) and Flashplate technology • Laboratory automation - Beckman Biomek 2000, Packard Topcount

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Jun 1993 - Sep 1996

Sugen, Inc.

Research Associate I / II, High-throughput Screening Department

• Responsible for high-throughput cell-based and biochemical screening projects to discover novel small molecule and natural extract inhibitors for several Receptor/Protein Tyrosine Kinases and Phosphatases • Screened compounds using ELISA techniques, assessed lead compounds using Immunoprecipitation, Western Analysis/SDS-PAGE • Trained in the automation and validation of screening assays on a Zymark Robotics System • Contributed to developing and implementing a windows-driven, UNIX-based relational database application for inventory and screening data processing and storage • Trained and advised other research associates in laboratory techniques and on the use of a screening database

Education

2012 - 2015

UC Berkeley Extension

Certificate, Project Management

1988 - 1993

UC Berkeley

BA Molecular and Cell Biology, Cell and Developmental Biology

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